Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A Convenient Synthesis of Pyridazino [4, 5-b] quinolines and Pyrrolo [3, 4-b] quinolines
YOSHIHISA KURASAWAATSUSHI TAKADA
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Keywords: ferrous ion
JOURNAL FREE ACCESS

1980 Volume 28 Issue 12 Pages 3457-3465

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Abstract
The reaction of N-(1, 2-bisethoxycarbonylvinyl)-o-aminoacetophenone (IVc) with an excess of hydrazines or guanidines gave 4-hydroxy-1-oxo-1, 2-dihydropyridazino [4, 5-b]-quinolines (Ia, b) or 1, 3-dioxo-1, 3-dihydropyrrolo [3, 4-b] quinolines (IIIc, d), respectively. It was found that 2, 3-bishydrazinocarbonyl-4-methylquinolines (VIa, b) were converted to 4-hydroxy-1-oxo-1, 2-dihydropyridazino [4, 5-b] quinolines (Ia, b) and 1, 3-dioxo-1, 3-dihydropyrrolo [3, 4-b] quinolines (IIIa, b) under different reaction conditions.
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© The Pharmaceutical Society of Japan
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