Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Potential Anticancer Agents. V. Cardiac Glycosides of Asclepias albicans (Asclepiadaceae)
KAZUHIRO KOIKECAROLYN BEVELLESUNILK. TALAPATRAGEOFFREYA. CORDELLNORMANR. FARNSWORTH
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Keywords: antitumor activity
JOURNAL FREE ACCESS

1980 Volume 28 Issue 2 Pages 401-405

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Abstract

The cytotoxic activity of extracts of Asclepias albicans (Asclepiadaceae) was traced to uzarigenin (2), desglucouzarin (3) and a new cardenolide glycoside, uzarigenin 3-O-β-D-glucopyranosyl (1→4)-β-D-glucopyranoside (4). The latter compound also displayed significant antitumor activity against P-388 lymphocytic leukemia.

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© The Pharmaceutical Society of Japan
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