The Influence of Bovine Thymus Hypocalcemic Protein, TP1, on the Levels of Cyclic Nucleotides in Murine Thymus Lymphocytes

Abstract

The effects of bovine thymus hypocalcemic protein (TP1) on cAMP and cGMP levels in murine thymus cells were studied. TP1 elevated cGMP levels 12.5-fold at a concentration of 0.15 mg/ml after incubation for 5 min but the amount of cAMP in thymocytes was lowered. These results suggest that TP1 stimulates the differentiation of early T-cells to mature T-cell subsets, such as helper cells, but does not stimulate that of stem cells to early T-cells.