Effect of Synthetic Serum Thymic Factor Fragments on the Inhibition of Sheep Erythrocyte Rosette Formation by Uremic Toxin

Abstract

Three peptide fragments of STF, H-Ser-Gln-Gly-Gly-Ser-Asn-OH, H-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH and H-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH, were synthesized by the solution method and their biological activities were investigated. The minimum fragment of STF able to show antagonistic action towards the E-rosette formation inhibition activity of MMS appears to be H-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH.