Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements

YOSHIAKI KISO; KAZUKO UKAWA; SHIZUO NAKAMURA; KAORU ITO; TADASHI AKITA

doi:10.1248/cpb.28.673

木曽良明, 宇川和子, 中村静夫, 伊藤薫, 秋田正

著者情報

キーワード: peptide synthesis

ジャーナルフリー

1980 年 28 巻 2 号 p. 673-676

DOI https://doi.org/10.1248/cpb.28.673

詳細

抄録

A thioanisole-trifluoroacetic acid (TFA) system was found to deprotect Tyr (Bzl) quantitatively at 25°within 3 hr by a push-pull mechanism without O-to-C rearrangements. This new deblocking system did not completely deprotect Ser (Bzl) and Thr (Bzl), but deprotected Lys (Z) quantitatively.

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