Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Butylated Hydroxyanisole-Nitrite Reaction : Effects on N-Nitrosodimethylamine Formation in Model Systems
TSUTAO KURECHIKIYOMI KIKUGAWATETSUTA KATO
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Keywords: Sustane
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1980 Volume 28 Issue 4 Pages 1314-1317

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Abstract
Butylated hydroxyanisole (BHA) prevented the formation of N-nitrosodimethylamine from dimethylamine and nitrite in a heterogeneous emulsion system. The reaction between BHA and nitrite was shown to yield 8 compounds, including 1-hydroxy-2-t-butyl-4-methoxy-6-nitrobenzene (I) as a major product.
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© The Pharmaceutical Society of Japan
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