Cyclic Guanidines. IX. Synthesis of 2-Amino-3, 4-dihydroquinazolines as Blood Platelet Aggregation Inhibitors

Abstract

A series of aryl-or aralky-substituted 2-amino-3, 4-dihydroquinazolines and related compounds were synthesized. The compounds were evaluated for inhibitory activity towards collagen-and ADP-induced aggregation of rat blood platelet in vitro and ex vivo. A group of 3-benzyl-substituted derivatives had potent activity. The structure-activity relationships are discussed.