Studies on Furan Derivatives. VIII. Preparation of Some New Nitrofuran Derivatives and Determination of Antibacterial Activity

Abstract

α-Substituted β-(5-nitro-2-furyl) ethanediones, α-substituted β-(5-nitro-2-furyl)-ethanedione β-oximes, α-substituted α-chloro-β-(5-nitro-2-furyl) vinyls, and 2-substituted 3-(5-nitro-2-furyl)-4-methylquinolines were prepared from aryl or 2-furyl 5-nitro-2-furfuryl ketones, which were easily obtained by the hydrolysis of α-aryl-or α-(2-furyl)-β-(5-nitro-2-furyl) vinylamines. α-Substituted β-(5-nitro-2-furyl) ethanedione β-oximes exhibited moderate antibacterial activity in vitro against gram-negative and gram-positive organisms.