Abstract
The reaction of sulpyrine with nitrite under mild conditions similar to those of the human stomach gave three N-nitroso compounds. The main products were 4-(N-methyl-N-nitroso) aminoantipyrine (I) and 1-diketobutyryl-1-phenyl-2-methyl-2-nitrosohydrazide hydrate (III), and 1-acetyl-1-methyl-2-nitroso-2-phenylhydrazine (II) was formed as a minor product. The possible pathways of formation of I and III are discussed.
