Synthesis of 1, 3-Bridged 1, 2, 3, 4, 5, 6-Hexahydro-2, 6-methano-3-benzazocine Derivatives

Abstract

Two 1, 3-bridged 1, 2, 3, 4, 5, 6-hexahydro-2, 6-methano-3-benzazocine derivatives (1 and 2) have been synthesized starting from 3, 6-dimethyl-8-methoxy-1, 2, 3, 4, 5, 6-hexahydro-2, 6-methano-3-benzazocine 3 as shown in Chart 1. Compounds 1 and 2 showed no significant analgesic activity.