Cyclic Guanidines. XI. Hydroxy and Aminoimidazo [2, 1-b]-quinazolines and Related Compounds

抄録

The Phenyl-substituted 1-methyl tricyclic guanidine (1) having an imidazo- or pyrimido-[2, 1-b] quinazoline ring was easily oxidized at the methine group adjacent to the aromatic rings to give the 5-hydroxy- or 6-hydroxy derivative (2), respectively. Reaction of 2-aminobenzophenone with 2-chloro-2-imidazoline gave the 1-unsubstituted 5-hydroxy-imidazo [2, 1-b] quinazoline derivative (5). The structures of compounds 2 and 5 are discussed. 1-Hydroxy- (13) and 1-amino tricyclic guanidines (16) were prepared by the reaction of 2-chloro-3-(2-chloroethyl)-4-phenyl-3, 4-dihydroquinazoline with hydroxylamine and hydrazine, respectively. Compounds 2, 5 and 13 showed hypoglycemic and platelet aggregation inhibitory activity.