Studies on Peptides. XCVII. Synthesis of Porcine Glu8-Vasoactive Intestinal Polypeptide (VIP)

MASAHARU TAKEYAMA; KANAME KOYAMA; HARUAKI YAJIMA; MOTOYUKI MORIGA; MITSURU AONO; MOTONOBU MURAKAMI

doi:10.1248/cpb.28.2265

Studies on Peptides. XCVII. Synthesis of Porcine Glu⁸-Vasoactive Intestinal Polypeptide (VIP)

MASAHARU TAKEYAMA, KANAME KOYAMA, HARUAKI YAJIMA, MOTOYUKI MORIGA, MITSURU AONO, MOTONOBU MURAKAMI

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Keywords: pancreatic secretory activity

JOURNAL FREE ACCESS

1980 Volume 28 Issue 7 Pages 2265-2269

DOI https://doi.org/10.1248/cpb.28.2265

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Abstract

The synthesis of Glu⁸-vasoactive intestinal polypeptide (porcine VIP) is described. A 1 M solution of trifluoromethanesulfonic acid-thioanisole (1 : 1 equiv.) in TFA was found to cleave all the protecting groups employed, Z, Z (OMe), Bzl and Mts, suppressing the acid-catalyzed aminosuccinimide formation of the Asp residue (position 3) with the free carboxyl group. The activity of Glu⁸-VIP was 1/7-1/8 of that of synthetic porcine VIP.

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