Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Structure-Activity Relationships in Tetramic Acids and Their Copper (II) Complexes
KEIZO MATSUOISAMU KITAGUCHIYOSHINORI TAKATAKUNIYOSHI TANAKA
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JOURNAL FREE ACCESS

1980 Volume 28 Issue 8 Pages 2494-2502

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Abstract
3-Acetyl and 3-decanoyltetramic acids with various substituents at the 5-position and their copper complexes, which possess a tricarbonylmethane structure, were prepared and tested for antimicrobial activity. 3-Decanoyltetramic acid derivatives and their copper complexes inhibited the growth of Bacillus subtilis and Staphylococcus aureus, but did not inhibited the growth of gram-negative bacteria and molds. 3-(1-Iminoethyl)-tetramic acids and their copper complexes were synthesized and tested for inhibitory activity towards chlorophyll development in plants.
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© The Pharmaceutical Society of Japan
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