Synthesis of the Metabolites of 2-(N-Benzyl-N-methylamino)ethyl Methyl 2, 6-Dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate Hydrochloride (Nicardipine Hydrochloride, YC-93)

TADAO SHIBANUMA; MASARU IWANAMI; MASAHARU FUJIMOTO; TOICHI TAKENAKA; MASUO MURAKAMI

doi:10.1248/cpb.28.2609

TADAO SHIBANUMA, MASARU IWANAMI, MASAHARU FUJIMOTO, TOICHI TAKENAKA, MASUO MURAKAMI

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Keywords: vasodilator

JOURNAL FREE ACCESS

1980 Volume 28 Issue 9 Pages 2609-2613

DOI https://doi.org/10.1248/cpb.28.2609

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Abstract

Eight metabolites (M-1-M-6, M-8, M-9) of 2-(N-benzyl-N-methylamino)ethyl methyl 2, 6-dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate hydrochloride (YC-93) were synthesized and the structures of the metabolites were established by comparison with the synthetic compounds.

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