4-Phenyl-2-(1-piperazinyl)quinolines with Potent Antidepressant Activity
1980 年 28 巻 9 号 p. 2618-2622
詳細
1980 年 28 巻 9 号 p. 2618-2622
A series of 2-amino-4-phenylquinolines was synthesized and the effects of these compounds on the central nervous system were evaluated pharmacologically in mice. Among these compounds, many 2-(substituted piperazinyl) derivatives exhibited a potent antagonism to hypothermia and catalepsy induced by reserpine, as well as some inhibitory effect on locomotor activity. Some compounds were found to possess activity to inhibit tremorine-induced tremor.
