Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Application of the Ammonia Selective Electrode : Determination of Meprobamate by Decomposition with Acid
SHOICHIRO TAGAMI
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1980 Volume 28 Issue 9 Pages 2642-2646

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Abstract

Meprobamate decomposes into NH4Cl, CO2, and a diol compound on heating in 20% HCl, and the NH3 evolved at pH above 11 can be determined using the NH3 selective electrode without separation from the decomposition solution. A linear calibration plot was obtained within the concentration range of 1×10-5-1×10-2M meprobamate. Volatile amines and the Hg ion, which forms a metal complex with NH3, are known to interfere with the electrode measurements.

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© The Pharmaceutical Society of Japan
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