Significance of Stomach-Emptying-Controlled Rabbits for GI Absorption Studies of Water-Soluble Drugs

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The usefulness of stomach-emptying-(SE-) controlled rabbits for GI absorption studies of relatively water-soluble drugs was investigated, employing aminopyrine and sulfisoxazole as model drugs. When aminopyrine was administered, similar plasma level-time curves were obtained in both SE-controlled and conventionally fasted rabbits. In the case of sulfisoxazole, the time required to reach the peak plasma level was much longer in conventionally fasted rabbits than in the SE-controlled group. It was concluded that use of conventionally fasted rabbits for GI absorption studies should be limited to work on water-soluble drugs.