Abstract
2-Substituted 3-(5-nitro-2-furyl) quinoxaline 1, 4-dioxides (Va-g) were prepared by the reaction of benzofurazan 1-oxide with α-aryl- or α-(2-furyl)-β-(5-nitro-2-furyl)-vinylamines and aryl or 2-furyl 5-nitro-2-furfuryl ketones. It was found that primary enamines, as well as tertiary enamines, are useful in this reaction. One-pot synthesis of 2-(2-furyl)-3-(5-nitro-2-furyl) quinoxaline 1, 4-dioxide (Va) from 2-[β-(5-nitro-2-furyl) ethynyl] furan was examined, and afforded Va in 11% yield. Compounds Va-g were subjected to antibacterial activity tests and some of them showed activity at 6.25-25μg/ml (minimal inhibitory concentration).
