Author's Organization：Faculty of Pharmaceutical Sciences, Science University of Tokyo Faculty of Pharmaceutical Sciences, Science University of Tokyo Faculty of Pharmaceutical Sciences, Science University of Tokyo
Treatment with conc. hydrochloric acid of p-quinol acetates (1) obtained from 7-hydroxy-1, 2, 3, 4-tetrahydroisoquinolines (4) gave the corresponding 8-chloro-7-hydroxy-1, 2, 3, 4-tetrahydroisoquinolines (5) in good yields. Similarly, by using conc. hydrobromic acid or 38% hydriodic acid, 8-bromo (6)- or 8-iodo-corypalline (7) was obtained.
