Synthesis and Selective Activity of Cholinergic Agents with Rigid Skeletons. II
1981 年 29 巻 10 号 p. 3019-3025
詳細
1981 年 29 巻 10 号 p. 3019-3025
Three types of compound, quinuclidine-3-spiro-2'-dioxolane (A), piperidine-4-spiro-2'-dioxolane (B), and piperidine-4-spiro-2'-(4'-oxodioxolane) (C) and their methiodides were synthesized. The cholinomimetic activities of these compounds were examined to investigate the relationship between the activities of these compounds, which have rigid skeletons, and those of known muscarinic agents.
