Utility of the Substituent Entropy Constants σso in the Studies of Quantitative Structure-Activity Relationships
キーワード:
local anesthetics
1981 年 29 巻 10 号 p. 3073-3075
詳細
1981 年 29 巻 10 号 p. 3073-3075
Values of the substituent entropy constants σso for monosubstituted methane and benzene derivatives were determined from the standard entropy of the 3rd law of thermodynamics. This parameter is orthogonal to σt or σπ, and seems preferable to π, Es, MR, Mw, Pr and Vw. Two examples of QSAR are successfully analysed in terms of σso.
