A New Method for the Synthesis of 2'-Amino-2'-deoxyguanosine and -adenosine and Their Derivatives

抄録

A new and simple procedure has been developed for the synthesis of 2'-amino-2'-deoxyguanosine (9) and -adenosine (15) and related compounds. An enzymatic transaminoribosylation between 2-chlorohypoxanthine (6) and 2'-amino-2'-deoxyuridine (4) afforded 9-(2-amino-2-deoxy-β-D-ribofuranosyl)-2-chlorohypoxanthine (8), which was chemically converted to 9 and its derivatives. 2'-Amino-2'-deoxyinosine (7) enzymatically prepared was also subjected to synthetic processes to give 15 and its derivative. The combination of chemical and enzymatic reactions was found to be useful for the synthesis of some sugar-modified purine nucleosides.