Abstract
Two thymopoietin fragments, H-Val-Thr-Leu-Pro-Ala-Gly-Glu-Gln-Arg-Lys-Asp-Val-Tyr-OH (positions 24-36) and H-Glu-Gln-Arg-Lys-Asp-Val-Tyr-OH (positions 30-36), were synthesized using protecting groups removable by hydrogen fluoride treatment. The in vitro additions of these synthetic fragments could restore the low E-rosette forming capacity of cells in a patient with lupus nephritis to normal levels. The in vitro effects of tridecapeptide (positions 24-36) and heptapeptide (positions 30-36) fragments of thymopoietin on the low E-rosette forming capacity of cells in a patient with lupus nephritis were also compared with that of the synthetic pentapeptide fragment (positions 32-36). The relative potency of the heptapeptide was 65.22 and that of the tridecapeptide was 40.54 based on the pentapeptide (100.00) as a standard.
