Effect of Escin on Adrenocorticotropin and Corticosterone Levels in Rat Plasma
キーワード:
diphenhydramine
1981 年 29 巻 2 号 p. 490-494
詳細
1981 年 29 巻 2 号 p. 490-494
The effect of β-escin on plasma adrenocorticotropin (ACTH) and corticosterone levels in rat plasma was determined by radioimmunoassay and by the competitive protein binding method. Intraperitoneal administration of β-escin induced increases of plasma ACTH and corticosterone in rats. The increase of plasma corticosterone was accompanied by a transient increase of plasma glucose and a transient decrease of plasma immunoreactive insulin. Hexamethonium partially suppressed the escin-induced corticosterone secretion, but diphenhydramine did not.
