Toxicological Approaches to Streptothricin Antibiotics. IV. Toxicity of Streptothricin Antibiotics to the Blood

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The hematoxicity of a streptothricin antibiotic was investigated in rats by blood morphological examination by scanning electron microscopic observation of changes in the erythrocytic membrane and by means of the coil planet centrifuge (CPC) technique to detect alterations in erythrocytic membrane dysfunction. The administration of the antibiotic caused no appreciable hematological change, nor any alteration in the morphology or function of the red blood cell membrane. The results indicate that the streptothricin antibiotic has no hematotoxic potential.