Identification of a Reactive Metabolite of the Mutagen, 2-Amino-3-methylimidazolo [4, 5-f] quinoline

TOSHIHIKO OKAMOTO; KOICHI SHUDO; YUICHI HASHIMOTO; TAKUO KOSUGE; TAKASHI SUGIMURA; SUSUMU NISHIMURA

doi:10.1248/cpb.29.590

TOSHIHIKO OKAMOTO, KOICHI SHUDO, YUICHI HASHIMOTO, TAKUO KOSUGE, TAKASHI SUGIMURA, SUSUMU NISHIMURA

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Keywords: DNA modification

JOURNAL FREE ACCESS

1981 Volume 29 Issue 2 Pages 590-593

DOI https://doi.org/10.1248/cpb.29.590

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Abstract

A reactive major metabolite of the mutagen, 2-amino-3-methylimidazolo [4, 5-f]-quinoline (IQ), by rat liver microsomes was 2-hydroxyamino-3-methylimidazolo [4, 5-f]-quinoline (N-OH-IQ). The synthesis and reaction with DNA of N-OH-IQ were discussed.

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