Synthesis and Antimicrobial Activity of Methyl 5-Nitro-3, 4-diphenylfuran-2-carboxylate and Related Compounds

Abstract

In order to investigate the antimicrobial activity of derivatives of methyl 5-nitro-3, 4-diphenylfuran-2-carboxylate, we first studied the optimal conditions for the nitration of methyl 3, 4-diphenylfuran-2-carboxylate. Starting from the nitrofuran methyl ester, various amides, hydrazides, hydrazones, oxadiazoles and thiazoles were synthesized and examined for antimicrobial activity. Most of the derivatives were active against T. vaginalis.