Determination of Sulthiame in Plasma by High-Performance Liquid Chromatography

抄録

A simple high-performance liquid chromatographic method for the determination of sulthiame, N-(4'-sulfamoylphenyl)-1, 4-butanesultam, in plasma is described. The method permits the accurate determination of the drug in plasma at concentrations as low as 150 ng/ml and is suitable for monitoring the drug in the therapeutic dose range and for investigation of the bioavailabilities of preparations of the drug.