Abstract
1-O-, 3-O-, and 6-O-acyl-D-glucopyranoses carrying capryloyl, lauroyl, myristoyl, palmitoyl, and stearoyl functions were tested for their in vivo and in vitro antitumor effects against Ehrlich ascites carcinoma in mice and a leukemia cell line L-5178Y by the total packed cell volume method and the tissue culture method, respectively. In the in vivo bioassay, the 1-and 3-myristate and the 6-stearate were moderately effective, while all other compounds exhibited little or no effect. These samples inhibited the growth of the cultured leukemia cells to various extents : relatively lower ID50 values were obtained with the 1-laurate, 1-myristate, 1-palmitate, 3-myristate, and 6-laurate. On the basis of these findings, the monoesters of monosaccharide appear to be less promising as antitumor agents than the analogous derivatives of disaccharide.
