抄録
Heating of methylquinolines (1, 3, 6, and 12) with phosphorus pentachloride in phosphoryl chloride gave the corresponding trichloromethylquinoline derivatives (2, 4, 9, and 14). Similar treatment of 4-chloro-2-methyl-3-nitroquinoline (16) gave 4-chloro-2-dichloromethyl-3-nitroquinoline (17), 4-chloro-3-nitro-2-trichloromethylquinoline (18), and 3, 4-dichloro-2-cyanoquinoline (19). The reaction of 2-trichloromethylquinolines (2, 9, and 18) with trimethyl phosphite gave the corresponding methylated products, 2-(1, 1-dichloroethyl) quinolines (21, 24, and 27). However, 4-trichloromethylquinolines (4 and 14) reacted with trimethyl phosphite under similar conditions to give 4-dichloromethylquinolines (23 and 13).
