A Direct Reductive Deamination of Amidines with Sodium Borohydride. Formation of Deaminated Compounds and Secondary Amines

Abstract

The reaction of 3-substituted-4-amino-1H-1, 5-benzodiazepines (1a, b) with sodium borohydride afforded deaminated compounds (4a, b and 6a, b). On the other hand, acyclic amidines were converted by treatment with sodium borohydride to the corresponding secondary amines (13) under the same conditions.