1981 年 29 巻 4 号 p. 1179-1181
The analgesic effects of the decomposition products of sulpyrine, N-[2-(5-hydroxymethyl-2, 3, 4, 5-tetrahydro-2, 3, 4-trihydroxy) furyl] methyl-N-methylantipyrine (MAAG) and antipyrinyl-4-peroxide (AP), which were reported by us previously, were determined by measurement of the inhibition of writhing caused by the injection of acetic acid into male mice, and compared with the effects of sulpyrine and antipyrine. MAAG and AP showed 62% and 48% of the potency of sulpyrine, respectively, in spite of having hydrophilic substituents. It is suggested that the analgesic effects of these compounds are intrinsic to the compounds themselves.
