Thiol Compounds. II. Synthesis and Antihypertensive Activity of Mercaptoacylamino Acids

Abstract

The synthesis and structure-activity relationship of a series of mercaptoacylamino acids are described. These compounds were tested for antihypertensive activity. When the compounds were screened as angiotensin I-converting enzyme inhibitors in vitro, N-(2-mercaptopropanoyl)-L-cysteine-a (7a) and N²-(2-mercaptopropanoyl)-L-tryptophan-a (20a) were found to be 10 and 20 times more active than tiopronin, respectively.