Mannich Reaction of Dihydropyridine Derivatives. II. Reaction with Primary Amines
1981 年 29 巻 5 号 p. 1193-1202
詳細
1981 年 29 巻 5 号 p. 1193-1202
Dialkyl 4-aryl-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarboxylates (I) were subjected to the Mannich reaction with excess paraformaldehyde and primary amine in ethanolic solution. Novel ring-system compounds, dialkyl t-6-aryl-1H, 6H-2, 3, 6a, 7, 8, 9-hexahydro-2, 3a, 8-triazaphenalene-5, γ-6a-dicarboxylate derivatives (III), and some intermediary products were obtained stereoselectively. The reaction pathway and the stereochemistry of these products are discussed.
