Synthesis of 12α and 12β-Carboxyestradiol Derivatives via the Thermal Elimination of β-Ketosulfoxide

Abstract

The unsaturated keto ester (3) prepared from the β-ketosulfoxide (2) by the mild thermal elimination was condensed with 2-methylcyclopentane-1, 3-dione to give the trione (4), which was converted into the novel title compounds (14) and (15).