Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A Resin-promoted Williamson's Alkyl Aryl Ether Synthesis. Methylation of 2-tert-Butyl-5-methylphenol with Methyl Chloride
YASUMASA HAMADANOBUHARU KATOYUKO KAKAMUTAKAYUKI SHIOIRI
Author information
JOURNAL FREE ACCESS

1981 Volume 29 Issue 8 Pages 2246-2250

Details
Abstract

The use of easily recoverable tri-n-butylphosphoniummethylated polystyrene resin (phosphonium resin catalyst) under triphasic reaction conditions was proposed in Williamson's alkyl aryl ether synthesis. O-Methylation of 2-tert-butyl-5-methylphenol with methyl chloride was easily carried out in the presence of the phosphonium resin catalyst under basic conditions to give 2-tert-butyl-5-methylphenyl methyl ether in excellent yield. A few other phenols were also O-alkylated under similar triphasic reaction conditions to give alkyl aryl ethers.

Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top