Metabolism of 9, 3"-Diacetylmidecamycin. II. The Structures of Several Metabolites of 9, 3"-Diacetylmidecamycin

TOMOKO SHOMURA; SAWAKO SOMEYA; SHINJIRO MURATA; KOSHIRO UMEMURA; MOTOHIRO NISHIO

doi:10.1248/cpb.29.2413

TOMOKO SHOMURA, SAWAKO SOMEYA, SHINJIRO MURATA, KOSHIRO UMEMURA, MOTOHIRO NISHIO

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Keywords: γ-gauche effect

JOURNAL FREE ACCESS

1981 Volume 29 Issue 9 Pages 2413-2419

DOI https://doi.org/10.1248/cpb.29.2413

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Abstract

The structures of several metabolites of 9, 3"-diacetylmidecamycin were studied by means of nuclear magnetic resonance (NMR) and mass spectroscopy. It was shown that these metabolites are a pair of 14-hydroxylated compounds which differ in the stereochemistry at carbon-14 of the macrocyclic lactone ring, and the corresponding 9-de-acetylated products.

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