A Convenient Preparation of N-Acylpyroglutamic Acid

KATSUHIRO IMAKI; HARUKI NIWA; SHIGERU SAKUYAMA; TAKANORI OKADA; MASAAKI TODA; MASAKI HAYASHI

doi:10.1248/cpb.29.2699

KATSUHIRO IMAKI, HARUKI NIWA, SHIGERU SAKUYAMA, TAKANORI OKADA, MASAAKI TODA, MASAKI HAYASHI

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Keywords: N-acetyl-L-pyroglutamic acid

JOURNAL FREE ACCESS

1981 Volume 29 Issue 9 Pages 2699-2701

DOI https://doi.org/10.1248/cpb.29.2699

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Abstract

Pyroglutamic acid reacted with acyl chloride in the presence of triethylamine in acetonitrile, yielding N-acylpyroglutamic acid without epimerization by way of mixed anhydride formation followed by intramolecular N-acylation.

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