Studies on Phosphonic Acid Antibiotics. IV. Synthesis and Antibacterial Activity of Analogs of 3-(N-Acetyl-N-hydroxyamino)-propylphosphonic Acid (FR-900098)

KEIJI HEMMI; KIDEKAZU TAKENO; MASASHI HASHIMOTO; TAKASHI KAMIYA

doi:10.1248/cpb.30.111

逸見恵次, 武野秀一, 橋本真志, 紙谷孝

著者情報

キーワード: Michaelis-Arubuzov reaction

ジャーナルフリー

1982 年 30 巻 1 号 p. 111-118

DOI https://doi.org/10.1248/cpb.30.111

詳細

抄録

The synthesis of analogs of 3-(N-acetyl-N-hydroxyamino) propylphosphonic acid (FR-900098, Ia) and an analysis of their structure-activity relationship are described. Among them, compounds Ib (FR-31564) and XIIb (FR-32863) have recently been found to be produced naturally by Streptomyces lavendulae. The antibacterial activity of Ib against Pseudomonas species is especially significant.

責任著者(Corresponding author)

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