Effects of Two Synthetic Serum Thymic Factor Analogues and Four Thymic Factor Fragments on the Low E-Rosette Forming Cells in Patients with Chronic Renal Failure

Abstract

Two new analogues of serum thymic factor (STF), [Dab³]- and [Asn⁵, Gln⁹]-STF and four thymic factor fragments, H-Lys-Ser-Gln-OH, H-Lys-Ser-Gln-Gly-OH, H-Lys-Ser-Gln-Gly-OH and H-Lys-Ser-Gln-Gly-Gly-Ser-OH, were synthesized by the solution method, and were tested to determine their effects on the low E-rosette forming cells in patients with chronic renal failure. The analogue [Dab³]-STF and three fragments, H-Lys-Ser-Gln-Gly-OH, H-Lys-Ser-Gln-Gly-Gly-OH and H-Lys-Ser-Gln-Gly-Gly-Ser-OH, increased E-rosette forming capacity when incubated in vitro with patient's blood, but [Asn⁵, Gln⁹]-STF and the tripeptide, H-Lys-Ser-Gln-OH, had no effect.