Studies on Pyrimidine Derivatives. XXVI. Synthesis of Derivatives containing a 1, 3-Dicarbonyl Side Chain

Abstract

Pyrimidine derivatives containing a 1, 3-dicarbonyl side chain at the 2-or 4-position were synthesized by the Claisen condensation of pyrimidine 2- or 4-carboxylic esters with ethyl acetate, acetophenone, and phenylacetonitrile. The keto-enol tautomerism of the products is also reported.