Release Profiles of 5-Fluorouracil and Its Derivatives from Polycarbonate Matrices in Vitro

抄録

Release profiles of 5-fluorouracil (5-FU), 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur, tegafur) and 1, 3-bis-(tetrahydro-2-furanyl)-5-fluorouracil (FD-1) from poly-(ethylene carbonate) and poly (propylene carbonate) pellets were examined in vitro. Because of poor compatibility of 5-FU with polycarbonates, 5-FU was quickly released from the pellets. Release of ftorafur from pellets of both polycarbonates was sustained. Release profiles of FD-1 from polycarbonate pellets were complex but extended. Release of ftorafur and FD-1 from pellets of a 9 : 1 mixture of poly (ethylene carbonate) and poly-(propylene carbonate) was less sustained than those from the individual polymers.