A One-Pot Synthesis of β-Lactams by the Reaction of β-Haloacyl Chlorides with α-Amino Acids
キーワード:
intramolecular N-alkylation
1982 年 30 巻 5 号 p. 1574-1578
詳細
1982 年 30 巻 5 号 p. 1574-1578
A one-pot synthesis of β-lactams (4) was successfully achieved by the reaction of β-haloacyl chlorides (1) with α-amino acids (2) in aqueous 5% sodium hydroxide solution in the absence of phase transfer catalyst in yields of 43-91%.
