Studies on Azole Compounds. VI. Reactions of 2, 4- and 2, 5-Disubstituted Thiazole N-Oxides with Aryl Isocyanates

Abstract

The reactions of 2, 4- (Ia-d) and 2, 5-disubstituted thiazole 3-oxides (Ie-f) with aryl isocyanates (II) were studied. While the reactions of Ia-d with II proceeded smoothly to give bis (5-imidazolyl) disulfides (IV), those of Ie-f with II did not take place. The structures of IV were deduced from their chemical behavior and spectral data. The reaction mechanism of Ia-d with II is discussed.