Suppression of IgM-producing Cells by Administration of Anti-IgM Serum in Vivo before Sheep Red Blood Cells Injection

抄録

The primary immune response in young adult mice to sheep red blood cells was studied by following the effects of anti-IgM or anti-Fc sera on the number of plaqueforming cells for IgM (dPFC) and IgG (iPFC) in the spleen. The number of dPFC in the case of administration of anti-IgM serum at 1 h before antigen injection was significantly decreased to 3.7±0.9/10⁶ spleen cells in comparison with the value of control serum (69.0±15.7/10⁶ spleen cells). However, the numbers of iPFC in the cases of both anti-IgM or control sera were similar. From these results, we suppose that progenitors of IgM-producing cells are different from progenitors of IgG-producing cells in adult mice.