1, 6-DIHYDRO-3 (2H)-PYRIDINONES AS SYNTHETIC INTERMEDIATES. STEREOSELECTIVE SYNTHESIS OF (±)-CORYNANTHEIDOL AND (±)-QUININE

Abstract

A new synthetic method is described for the cis-3, 4-disubstituted piperidine compounds starting from ethyl 1, 6-dihydro-3 (2H)-pyridinone-1-carboxylate (1). Total synthesis of (±)-corynantheidol (3) and formal synthesis of (±)-quinine (4) were accomplished by an application of this method.