Solution Synthesis of a Heptacosapeptide known as Bovine γ3-Melanotropin (γ3-MSH)

SHINICHI SHIMAMURA; KOICHI YASUMURA; KENJI OKAMOTO; KENJI MIYATA; AKIRA TANAKA; MASUHISA NAKAMURA; KENICHI AKAJI; HARUAKI YAJIMA

doi:10.1248/cpb.30.2433

Solution Synthesis of a Heptacosapeptide known as Bovine γ₃-Melanotropin (γ₃-MSH)

SHINICHI SHIMAMURA, KOICHI YASUMURA, KENJI OKAMOTO, KENJI MIYATA, AKIRA TANAKA, MASUHISA NAKAMURA, KENICHI AKAJI, HARUAKI YAJIMA

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Keywords: digestion by carboxypeptidase P

JOURNAL FREE ACCESS

1982 Volume 30 Issue 7 Pages 2433-2439

DOI https://doi.org/10.1248/cpb.30.2433

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Abstract

A heptacosapeptide (known as γ₃-MSH) which is located within the amino acid sequence of bovine corticotropin-β-lipotropin precursor protein was synthesized by fragment condensation of Z-(1-12)-OSu and H-(13-27)-OBzl followed by deprotection with trifluoromethanesulfonic acid-thioanisole in TFA. The synthetic peptide exhibited weak melanocyte-stimulating activity (1.5×10⁶ U/g, in vitro).

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