SYNTHESIS AND IMMUNOSTIMULATING ACTIVITY OF FK-156 ANALOGUES : FATTY ACID DERIVATIVES OF N-[Nα-(γ-D-GLUTAMYL)-L-LYSYL]-D-ALANINE

Yoshihiko Kitaura; Hidekazu Takeno; Satoshi Okada; Osamu Nakaguchi; Keiji Hemmi; Yasuhiro Mine; Joh Mori; Masashi Hashimoto

doi:10.1248/cpb.30.3065

SYNTHESIS AND IMMUNOSTIMULATING ACTIVITY OF FK-156 ANALOGUES : FATTY ACID DERIVATIVES OF N-[N^α-(γ-D-GLUTAMYL)-L-LYSYL]-D-ALANINE

Yoshihiko Kitaura, Hidekazu Takeno, Satoshi Okada, Osamu Nakaguchi, Keiji Hemmi, Yasuhiro Mine, Joh Mori, Masashi Hashimoto

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Keywords: tumor-suppression

JOURNAL FREE ACCESS

1982 Volume 30 Issue 8 Pages 3065-3068

DOI https://doi.org/10.1248/cpb.30.3065

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Abstract

The fatty acid derivatives 3a, b of bacterial cell-wall peptidoglycan peptides related to FK-156 (1) were synthesized and their immunostimulating activities were examined. The new compounds 3a, b showed significant antiinfectious potencies comparable to that of 1 and 3b especially exhibited a potent tumor-suppressive property lacking in 1.

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