Author's Organization：Faculty of Pharmaceutical Sciences, Osaka University Faculty of Pharmaceutical Sciences, Osaka University Faculty of Pharmacy, Kinki University Faculty of Pharmaceutical Sciences, Osaka University
The novel substituent entropy constant σs° represents the molecular connectivity X, one of the QSAR descriptors developed by molecular topology. It is closely correlated with chromatographic retention data, such as retention time Rt or RT, and with retention index R.I. and specific retention volume Vg. Also, water solubility, boiling point and partition coefficient are represented by σs°.
