Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Inhibitors of Xanthine Oxidase from the Flowers and Buds of Daphne genkwa
TADATAKA NOROYASUSHI ODATOSHIO MIYASEAKIRA UENOSEIGO FUKUSHIMA
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Keywords: luteolin
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1983 Volume 31 Issue 11 Pages 3984-3987

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Abstract

Xanthine oxidase (XO) inhibitors were isolated from the flowers and buds of Daphne genkwa SIEB. et ZUCC. (Thymelaeaceae) and were identified as genkwanin (1), apigenin (2), luteolin 7-methyl ether (3) and luteolin (4). Compounds 2 and 4 showed particularly strong inhibitory activity against XO. The modes of inhibition by 2 and 4 with respect to xanthine as a substrate were of mixed type. This is the first report of isolation of 3 and 4 from these flowers and buds.

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© The Pharmaceutical Society of Japan
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